| George Washington, 1789-1797 | Martha Dandridge Custis Washington |
| John Adams, 1797-1801 | Abigail Smith Adams |
| Thomas Jefferson, 1801-1809 | Martha Wayles Skelton Jefferson |
| James Madison, 1809-1817 | Dolley Payne Todd Madison |
| James Monroe, 1817-1825 | Elizabeth Kortright Monroe |
| John Quincy Adams, 1825-1829 | Louisa Catherine Johnson Adams |
| Andrew Jackson, 1829-1837 | Rachel Donelson Jackson |
| Martin Van Buren, 1837-1841 | Hannah Hoes Van Buren |
| William Henry Harrison, 1841 | Anna Tuthill Symmes Harrison |
| John Tyler, 1841-1845 | Letitia Christian Tyler |
| Julia Gardiner Tyler | |
| James Knox Polk, 1845-1849 | Sarah Childress Polk |
| Zachary Taylor, 1849-1850 | Margaret Mackall Smith Taylor |
| Millard Fillmore, 1850-1853 | Abigail Powers Fillmore |
| Franklin Pierce, 1853-1857 | Jane Means Appleton Pierce |
| James Buchanan, 1857-1861 | Harriet Lane The Niece of President James Buchanan |
| Abraham Lincoln, 1861-1865 | Mary Todd Lincoln |
| Andrew Johnson, 1865-1869 | Eliza McCardle Johnson |
| Ulysses Simpson Grant, 1869-1877 | Julia Dent Grant |
| Rutherford Birchard Hayes, 1877-1881 | Lucy Ware Webb Hayes |
| James Abram Garfield, 1881 | Lucretia Rudolph Garfield |
| Chester Alan Arthur, 1881-1885 | Ellen Lewis Herndon Arthur |
| Grover Cleveland, 1885-1889 | Frances Folsom Cleveland |
| Benjamin Harrison, 1889-1893 | Caroline Lavina Scott Harrison |
| Grover Cleveland, 1893-1897 | Frances Folsom Cleveland |
| William McKinley, 1897-1901 | Ida Saxton McKinley |
| Theodore Roosevelt, 1901-1909 | Edith Kermit Carow Roosevelt |
| William Howard Taft, 1909-1913 | Helen Herron Taft |
| Woodrow Wilson, 1913-1921 | Ellen Louise Axson Wilson |
| Edith Bolling Galt Wilson | |
| Warren Gamaliel Harding, 1921-1923 | Florence Kling Harding |
| Calvin Coolidge, 1923-1929 | Grace Anna Goodhue Coolidge |
| Herbert Clark Hoover, 1929-1933 | Lou Henry Hoover |
| Franklin Delano Roosevelt, 1933-1945 | Anna Eleanor Roosevelt |
| Harry S. Truman, 1945-1953 | Elizabeth Virginia Wallace Truman |
| Dwight David Eisenhower 1953-1961 | Mamie Geneva Doud Eisenhower |
| John Fitzgerald Kennedy, 1961-1963 | Jacqueline Lee Bouvier Kennedy |
| Lyndon Baines Johnson, 1963-1969 | Claudia Taylor Johnson |
| Richard Milhouse Nixon, 1969-1974 | Patricia Ryan Nixon |
| Gerald Rudolph Ford, 1974-1977 | Elizabeth Bloomer Ford |
| James Earl Carter, Jr., 1977-1981 | Rosalynn Smith Carter |
| Ronald Wilson Reagan, 1981-1989 | Nancy Davis Reagan |
| George Herbert Walker Bush, 1989-1993 | Barbara Pierce Bush |
| William Jefferson Clinton, 1993-2001 | Hillary Rodham Clinton |
| George Walker Bush, 2001- | Laura Welch Bush |